Mathematical Model of MDR-TB and XDR-TB with Isolation and Lost to Follow-Up

MDR-TB and XDR-TB: drug resistance and treatment outcomes.

The subject is quite topical, as TB programmes and clinicians are searching for solutions to treat MDR/XDR-TB most effectively. Recently published studies and a systematic review have shown that XDR-TB is associated with higher probability of failure and death, and lower probability of treatment success than MDR-TB [2–7]. The XDR-TB-defining drugs have been studied to evaluate their role in det...

MDR / XDR - TB : where do we stand ?

Tuberculosis (TB) is one of the leading causes of death due to an infectious disease, second only to HIV/AIDS worldwide. It is estimated that approximately one third of the world’s population is infected with Mycobacterium tuberculosis, and 10% of infected individuals will develop active TB at some point in their lives. MDR-TB or multidrugresistant tuberculosis is a specific form of drug resist...

Early outcomes in MDR-TB and XDR-TB patients treated with delamanid under compassionate use.

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) remain significant global health challenges, with an annual incidence of approximately 480000 and 46000 cases, respectively [1]. Treatment outcomes in MDR-TB patients remain poor overall (52% success) and outcomes in XDR-TB patients are even more dismal (28% success) [1–3]. To improve these outcomes, new drugs are ...

Statistics & Information of MDR and XDR TB in SAARC Region

Declaration on palliative care and MDR/XDR-TB.

THE WORLD Health Organization (WHO) estimated a prevalence of 650 000 cases of multidrug-r esistant tuberculosis (MDR-TB) in 2010. Although efforts to improve cure rates in drug-resistant TB are vital, the global average reported cure rate was 53%. 1 Meanwhile, at least 150 000 deaths occur annually due to MDR-TB. 2 Efforts to provide palliative and end-of-life care to those suffering from this...